Statistics

PopViz is supporting 13,681,468 variants of 20,437 genes, based on WES data in 123,136 individuals from 7 populations. The data was collected from gnomAD database and processed according to the selection crteria mentioned in the introduction section.

   Statistics of Mutation Damaging Scores
MUTATION DAMAGE SCORE Number of Variants Matched with gnomAD Number of Pre-Computed Variants Stored in PopViz
CADD 13,681,468 509,303,619
EIGEN 5,641,271 81,366,024
LINSIGHT 4,708,171 403,864,908
SIFT 4,488,610 .
PolyPhen2 4,875,989 .


   Statistics of Mutation Consequences
CONSEQUENCES Number of Variants in PopViz
3' UTR 388,811
5' UTR 231,281
Frameshift 204,977
Inframe Deletion 56,117
Inframe Insertion 12,849
Intronic 4,800,908
Missense 4,884,607
Splice Acceptor 37,039
Splice Donor 46,541
Splice Region 526,300
Start Lost 10,712
Stop Gained 142,176
Stop Lost 4,936
Synonymous 2,334,214


   Statistics of IMPACT
IMPACT Number of Variants in PopViz
HIGH 446,381
MODERATE 4,953,573
MODIFIER 5,421,000
LOW 2,860,514


   Statistics of LoF
LOSS of FUNCTION Number of Variants in PopViz
HIGH-Confidence LoF 395,377
LOW-Confidence LoF 29,374
N.A. 13,256,717